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Product Info | VC-IP

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Update time : 2022-09-21 16:35:43
Greenway Supply VC-IP(Ascorbyl Tetraisopalmitate)
Oil-Soluble Vitamin C Derivative
INCI Name : Ascorbyl Tetraisopalmitate
Vitamin C has many functions as a cosmetic ingredient, including skin lightening, promoting collagen synthesis and inhibiting lipid peroxidation. VC-IP (ascorbyl tetraisopalmitate) is stable at   high temperatures and has good solubility in oils. VC-IP exhibits excellent percutaneous absorption and effectively converts into free vitamin C in the skin to perform various physiological functions. VC-IP is approved as a quasi-drug active in Japan (at 3%). It is also registered in Korea as a functional ingredient for skin lightening at 2% concentration.

Properties of VC-IP
Superior percutaneous absorption
Inhibits activity of intracellular tyrosinase and melanogenesis (whitening)
Reduces UV-induced cell / DNA damage (UV protection / anti-stress)
Prevents lipid peroxidation and skin aging (anti-oxidant)
Good solubility in common cosmetic oils
SOD-like activity (anti-oxidant)
Collagen synthesis and collagen protection (anti-age)
Heat- and oxidation-stable

Physical properties of VC-IP
Specific gravity (d2020)
Refractive Index (n25D )
:Colorless to pale yellow liquid
: 0.930 - 0.943
: 1.459 - 1.465
Skin Lightening / Anti-Pigmentation  
Inhibition of Melanogenesis
Various concentrations of VC-IP were added to cultured human melanoma cells (HM-3-KO). After 4 days of cultivation, the amount of melanin produced was measured by observation of the color tone of each cell pellet. As shown below, VC-IP effectively inhibited melanogenesis in human melanoma cells. Results were dose-dependent.
Inhibition of Intracellular Tyrosinase Activity
VC-IP was added into mouse melanoma cells (B16-4A5) at various concentrations. After a 72-hour cultivation, the cells were dissolved and extracted. L-Dopa was then added to the extract. After 60 minutes at 37, the amount of dopachrome formed by the activity of tyrosinase was evaluated by measuring its absorbance at 540 nm. Figure below shows that at a concentration of 0.02% and above VC-IP inhibited the activity of intracellular tyrosinase.

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