Glutathione exists in both reduced (GSH) and oxidized (GSSG) states. In the reduced state, the thiol group of cysteine is able to donate a reducing equivalent (H++ e−) to other molecules, such as reactive oxygen species to neutralize them, or to protein cysteines to maintain their reduced forms. With donating an electron, glutathione itself becomes reactive and readily reacts with another reactive glutathione to form glutathione disulfide (GSSG). Such a reaction is probable due to the relatively high concentration of glutathione in cells (up to 7 mM in the liver).
Generally, interactions between GSH and other molecules with higher relative electrophilicity deplete GSH levels within the cell. An exception to this case involves the sensitivity of GSH to the electrophilic compound's relative concentration. In high concentrations, the organic molecule Diethyl maleate fully depleted GSH levels in cells. However, in low concentrations, a minor decrease in cellular GSH levels was followed by a two-fold increase.
Product Name |
Glutathione powder |
Specification |
98% |
Test Method |
HPLC |
CAS.NO |
70-18-8 |
Molecular Formula |
C10H17N3O6S |
Inspection Standard |
Enterprise Standard Nutraceuticals Grade |
Structure |
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Function:
1. Raw Material Glutathione Reduced role of clinical treatment and prevention
(1) To protect the liver, detoxification, inactivation of hormones, and to promote bile acid metabolism and help absorb fat and fat-soluble vitamins digestive tract.
(2) Anti-allergy, or inflammation caused by hypoxemia in patients with systemic or local, can reduce cell damage and promote repair.
(3) To improve the course of certain diseases and symptoms as adjuvant drugs. Such as: hepatitis, hemolytic disease, and keratitis, cataract and retinal diseases, such as eye disease and improve vision.
2. Food additives
(1) added to pasta, to make manufacturers reduce the time of bread to the original one-half or one third, and serve to strengthen the role of food nutrition and other features.
(2) to add to the yogurt and baby food, the equivalent of vitamin C, can play a stabilizing agent.
(3) in its mix to the surimi to prevent color deepened.
(4) to the meat and cheese and other foods, have enhanced the effect of flavor.
3. Beauty products
Prevent the infiltration of Los tyrosinase in order to achieve the purpose of inhibiting melanin formation. On eliminate wrinkles, increase skin elasticity, shrink pores, lighten pigment, the body has an excellent whitening effect. Glutathione as the main ingredient in cosmetic products in Europe and the United States was welcomed by the decades.
| IDENTIFICATION . A. INFRARED ABSORPTION〈197K〉 . B. OPTICAL ROTATION, Specific Rotation〈781S〉 Sample solution: 40 mg/mL in water Acceptance criteria: − 15.5。to − 17.5。, at 20。 ASSAY . PROCEDURE Sample: 500 mg of glutathione previously dried Titrimetric system (See Titrimetry〈541〉 .) Mode: Direct titration Titrant: 0.1 N iodine VS Endpoint detection: Visual Blank: 50 mL of metaphosphoric acid (1 in 50) Analysis: Dissolve the Sample in 50 mL of metaphos- phoric acid (1 in 50) and titrate with the Titrant. Calculate the percentage of glutathione (C10 H17 N3O6S) in the portion of Glutathione taken: Result = [(V − B) × N × F × 100]/W V = titrant volume of the Sample (mL) B = titrant volume of the Blank (mL) N = titrant normality (mEq/mL) F = equivalency factor, 307.32 mg/mEq W = weight of the Sample (mg) Acceptance criteria: 98.0%– 101.0% on the dried basis IMPURITIES Inorganic Impurities . AMMONIUM Standard solution: 10 µg of ammonium from a diluted ammonium chloride solution Sample solution: 50 mg of Glutathione Analysis: Transfer the Sample solution and the Standard solution to separate 25-mL jars fitted with caps, and dissolve in 1 mL of water. Add 0.30 g of magnesium oxide. Close immediately after placing a piece of silver manganese paper 5-mm square, wetted with a few drops of water, under the caps. Swirl, avoiding projections of liquid, and allow to stand at 40。for 30 min. Acceptance criteria: If the silver manganese paper shows a gray color, it is not more intense than the standard (NMT 200 ppm). . ARSENIC〈211〉: NMT 2 ppm . CHLORIDE AND S Review Get our latest Products in your inbox
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