| Melatonin | ||
| CAS：73-31-4 | MF：C13H16N2O2 | MW：232.28 |
| Description: White or off-white crystalline powder, melting point 116.5-118 °C. Melatonin has good light and thermal stability, slightly soluble in water, easily soluble in hot water and propylene glycol, soluble in aqueous ethanol, acid, alkali and salt water, insoluble in other organic solvents and oils, maximum UV absorption wavelength is 728 nm and has intrinsic fluorescence. | ||
| Uses: It is a hormone secreted by the pineal body of the pituitary gland in the body. The amount of this hormone secreted is related to light. The weaker the light, the more secreted it is, and vice versa, the less it is to help sleep. Used in medical and health products, it can enhance the immune function of the human body, prevent aging and restore youth, and is a natural "sleeping pill". | ||
| Property description: A hormone secreted by pineal cells, pineal hormone, also known as melatonin, is a hormone secreted by pineal cells, its chemical structure is 5-methoxy-N-acetylene Tryptamine, its physiological role is to inhibit gonad, thyroid, adrenal, parathyroid and pituitary functions, inhibit precocious puberty in children, reduce pituitary melanin secretion; and has central nervous system effects, can increase the threshold of convulsions, cause drowsiness, etc. When the pineal gland was removed, the experimental animals showed that the aforementioned glands were hypertrophied and increased in weight, especially the precocious gonads and sexual organs of immature rats, the secretion of LH and FSH from the pituitary increased, and the secretion of thyroid and adrenal cortex hormones increased. Pineal hormone also reduces pituitary MSH and whitens the skin. This element acts on the central nervous system, showing a slow rhythm on the human EEG, increasing the convulsion threshold, and lethargy, but does not affect their behavior and personality. Electrogram changes. | ||
| Pineal gland: The pineal gland is shaped like a pine cone, about 7 mm long, 5 mm wide, 4 mm thick, and weighs 140-200 mg. It is located above the superior colliculus of the midbrain, followed by the great cerebral vein, and the back of the corpus callosum covers it. The ependyma originates from the roof of the third ventricle in the embryonic stage and protrudes upward from it. Most of it is encased by the pia mater, the connective tissue of the pia mater extending inward and dividing the pineal gland into irregular lobules. Postganglionic fibers of the sympathetic superior cervical ganglion accompany blood vessels into the pineal gland. The pineal gland is composed of a large number of pineal cells and a small amount of glial cells. The pineal cells are polygonal, long cylindrical or oval, with different lengths of cell processes. The cytoplasm is basophilic and often contains lipids. Droplets, large nuclei, irregularly depressed or lobulated, with nucleoli. Under the electron microscope, the Golgi complex can be seen in the cytoplasm, the rough endoplasmic reticulum is rich, and it is rich in free ribosomes, lysosomes, and a large number of microtubules and secretory granule vesicles. Contains norepinephrine, dopamine, serotonin and pineal hormone, also known as melatonin. Glial cells also have protrusions, oval nuclei, and dark nuclear and cytoplasmic staining. Under the electron microscope, there are also rough endoplasmic reticulum and free nucleosomes in the cytoplasm. They are rich in microfilaments and can be similar to pineal cells. the difference. There are also many solidified bodies in the pineal body, containing hydroxyapatite and calcium carbonate apatite, which often form mulberry-shaped small pieces, called brain sand, the size and number of which increase with age. | ||
| Synthesis and release of pineal hormone: Pineal cells take tryptophan from the blood circulation and convert it into 5-hydroxytryptophan under the catalysis of hydroxylase, which is decarboxylated to 5-hydroxytryptamine by decarboxylase, and 5-hydroxytryptamine has three One possible transformation: one part is deaminated by monoamine oxidase to 5-hydroxy-indoleacetic acid; another part leaves the pineal cell and is taken up by sympathetic nerve terminals and stored together with the neurotransmitter norepinephrine; the third part is absorbed by N -Acetylated by acetyl serotonin transferase, which in turn is o-methoxylated by hydroxyindole-o-methyltransferase to form melatonin. After the synthesis of melatonin, it may be released by cells into the blood circulation or enter the blood circulation through the cerebrospinal fluid. Norepinephrine can enhance its synthesis, and its speed depends on the activity of hydroxylase in the hepatocyte microsomes. - Hydroxymelatonin, which is subsequently excreted in the urine in combination with glucuronic acid and sulfate. | ||
Physiological effects of the pineal gland:
|
||
Hot tags: melatonin powder;pure melatonin powder;raw powders melatonin;bulk melatonin powder;buy melatonin powder;wholesale melatonin powder;melatonin powder for sale;Cas 73-31-4; Melatonine; Melatonin Supplier; Melatonin Factory; Melatonin Maufacturer;
