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Sep.2022 07
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Product Info | Sepiwhite Powder
Details
SEPIWHITETM  MSH

Characteristics
 
  INCI name Undecylenoyl Phenylalanine
Use level: 2%
Solubility: Hydrodispersible
Description: Powder
Preservatives None
Claims: Lightening, anti-dark spots
Available SEPIWHITE MSH QD for Japanese Quasi Drug formulas
 
Emulsions: introduction in water or oily phase (≥60°C)
 pH<5 and pH≥6.8: all types of formulas
 5<pH>6.8: addition of ethanol
Water-soluble at pH≥7 for clear solutions (neutralization with a weak base recommended)
China Compliant: all INCI names are listed on the IECIC 2015 - ECOCERT Cosmetics: raw material approved by   ECOCERT GREENLIFE, in conformity with Ecocert natural and organic cosmetic standard - Bio-Based & Naturality Profile: NOI=1 or NOC=100% according to ISO 16128, and 100% BIO-BASED according EN 16785 (based on 14C   analysis ASTM D 6866 & elemental analysis (C,H,O,N)).
 
 
SEPIWHITE MSH

Superfast lightening effect on phototype IV & V
 
After 7 Days
In Vivo Protocol:
21 days - 2% SEPIWHITEMSH + Lactic acid 3% + Salicylic acid 2% (formula EU07034)           22volunteers / phototypes IV and V (11 african + 11 Indian skin types) / average age 34 years old Forearms/ 2 applications per day
Spectrocolorimeter / Self evaluation / pictures
   
Skin luminosity Lightening effect  
 



A strong decrease for 83% of
the concerned volunteers   with spots
 
 
Inhibition of all key steps in the
α-MSH-induced melanogenic cascade

Strong affinity of SEPIWHITE MSH with
the  α-MSH-receptor MC1R (96%)
MC1R: melanocytes transmembrane receptor, activated by α-MSH. It stimulates the eumelanin (brown-black pigment) synthesis cascade   α-MSH: hormone causing melanin synthesis in response to UV rays
Inhibits adenylate cyclase 100%
Adenylate cyclase: transmembrane protein activated by MC1R, it produces cAMP fromATP
Decreases amount of intracellular cAMP in
melanocytes  by 34%
cAMP: second messenger, enables transduction of a signal from the exterior to the interior of the cell
Inhibits protein kinase A 100%
 

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