Ivermectin

Product Name: Ivermectin Powder
Appearance: White Powder
Sample: Ivermectin Avaliable
Assay: 99%
Other Names: Ivermectin
Mf: C95h146o28
Certificate: GMP ISO USP Bp
Description

 

Hot Sale CAS 70288-86-7 Ivermectin Powder

Ivermectin is widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod,
canine intestinal nematodes, ear mites, scabies mites, silk worm and microfilariae, gastrointestinal nematodes and external parasites and poultry. This product belong to the broad-spectrum resistant parasites. Ivermectin for a variety of most of the life cycle of nematodes (but not all nematodes) role; For dish tail filarial microfilariae effectively, but for adult worms; For only in intestinal fecal round worms are also effective. Ivermectin has the selective inhibitory effect, with no spinal nerve cells and muscle cells in the animal glutamic acid ion channels of the valve is the high binding affinity, leading to the proliferation of the chloride ion permeability of cell membrane, cause nerve cells or muscle cells hyperpolarization, parasites paralysis or death.

 

Tea egcg/egcg green tea extract/epicatechin


 
 Product Name:  Ivermectin
 Cas No.:   70288-86-7
 Spec./Purity:   99%
 Appearance:   White Fine Powder
 Molecular formula:     C48H74O14
 Partical size:  100% pass 80 mesh
 Shelf Life:  2 Years


Product Function  


1. Ivermectin is the derivatives of abamectin. Ivermectin belongs to semisynthetic broad-spectrum resistant parasites.

2. Ivermectin has effect for most of the various life cycle nematodes.

3. Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.

4. Ivermectin has effect for dung round worms that is only stay in intestinal tract.

5. Ivermectin has selective inhibition.

6. Ivermectin can not go through the blood brain barrier of humanbeings.



Application 


In veterinary medicine ivermectin powder is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage.

It is sometimes administered in combination with other medications to treat a broad spectrum of animal parasites. Some dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and the Australian Shepherd), though, have a high incidence of a certain mutation within the MDR1 gene (coding for P-glycoprotein); affected animals are particularly sensitive to the toxic effects of ivermectin.

Clinical evidence suggests kittens are susceptible to ivermectin toxicity. A 0.01% ivermectin topical preparation for treating ear mites in cats (Acarexx) is available.

Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated.


Certificate of Analysis 



 

Item Specification Results
Characters
Appearance
Solubility
 
White or yellowish-white crystalline powder
Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol
 
Conform
Identification
IR
HPLC
 
Conform
Conform
 
Conform Conform
Appearance of solution Solution is clear, BY7 Solution is clear, BY7
Specific optical rotation -17°~ -20° -18.3°
Related substances Impurity(1.3 2.5% 1.7%
Any other specified impurity  
1.0%
A:0.3 E:0.3 H:0.1 J4:0.4 F or I (RRT0.86):0.2
F or I (RRT1.56):0.1
Any unspecified impurity 0.20% RRT1.11: 0.06
Total impurities 5.0% 3.2%
Ethanol 5.0% 3.4%
Formamide 3.0% 2.5%
Heavy metals 0.002% <0.002
Water 1.0% 0.07%
Sulfated ash 0.1% 0.04%
Then content of    
(H2B1a+H2B1b) 95.0%-102.0% 98.1%
H2B1a/(H2B1a+H2B1b) 90.0% 98.0%

 

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