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Product Info - Tadalafil Powder

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Update time : 2022-09-01 14:55:21

Tadalafil
CAS No. : 171596-29-5  
Formula: C22H19N3O4
M.Wt: 389.4
Synonyms: Cialis,ICOS 351,Ic351,IC 351,IC-351 Metabolism
Target: PDE
Pathway: Store at -20°C
Storage: A4327
Solvent & Solubility
In Vitro insoluble in H2O; insoluble in EtOH;  ≥16.6 mg/mL in DMSO
Preparing
Stock Solutions
Mass 1mg 5mg 10mg
Solvent
Concentration
1 mM 2.5681 mL 12.8403 mL 25.6805 mL
5 mM 0.5136 mL 2.5681 mL 5.1361 mL
10 mM 0.2568 mL 1.2840 mL 2.5681 mL
Biological Activity
In Vitro Cell Viability Assay
Cell Line: human hepatocytes
Preparation method The solubility of this compound in DMSO is >16.6mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored
below -20°C for several months.
Reacting conditions: 1 pM
Applications: Tadalafil (1 μM) increased CYP3A protein expression in human hepatocytes.
In Vivo Animal experiment
Animal models: Rat model with bilateral cavernous neurotomy (BCN)-induced penile damage
and hypo-oxygenation, Mice with cavernous nerve resection
Dosage form: 2 mg/kg, daily for 3 months
Applications: Tadalafil  (2  mg/kg)  almost  completely  restored  penile  oxygenation  and abolished neurotomy induced increase and substantially rescued muscle/fiber ratio in penile sectionsin sham-operated rats. Tadalafil decreased the number of  apoptotic  cells  and  increased  the  phosphorylation  of  the  2  survival
associated kinases Akt and extracellular signal-regulated kinase 1/2 in mice.
Other notes: Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental
system error and it is normal.

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