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Buy Pure Tadalafil Powder for Sale | API Supplier | Greenway Biotech Wholesaler
Unlock a Satisfying Sex Life with Tadalafil Powder: Your Solution for ED and Premature Ejaculation. Are you seeking an effective solution for erectile dysfunction (ED) and premature ejaculation? Look no further than Tadalafil Powder. With its impressive track record and widespread use, this oral medication has helped millions of individuals regain their sexual confidence and enjoy fulfilling intimate experiences.
Powerful Benefits of Tadalafil Powder:
√ Combat ED and premature ejaculation with remarkable efficacy
√ Supported by a wealth of clinical evidence, with over 1500 documented cases
√ Proven long-term stability and safety, trusted by a global user base
√ Rapid onset of action, typically within 25 to 60 minutes, aligning perfectly with foreplay
√ Promote mutual satisfaction and intimacy, enhancing the overall sexual experience
√ Explore our comprehensive Questions and Answers section to learn more about Tadalafil Powder and how it can transform your sex life.
Note: Prior to using Tadalafil Powder or any medication, it is crucial to conduct thorough research and consult with a healthcare professional to ensure suitability and safety.

Product Name:	Tadalafil
CAS No.:	171596-29-5
Spec./Purity:	99%
Appearance:	White powder
Test Method:	HPLC
Partical size:	100% pass 80 mesh
Shelf Life:	2 Years
Certificates	COA (Click to see)

Product Details

Summary	Tadalafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary hypertension.
Generic Name	Tadalafil/Tadanafil
Background	Tadalafil is a selective phosphodiesterase 5 inhibitor used to treat erectile dysfunction (ED), pulmonary hypertension (PAH), and benign prostatic hypertrophy.It was first approved by the FDA in 2003 for ED and later in 2009 for PAH. Compared with other PDE5 inhibitors such as sildenafil, tadalafil has a higher selectivity for PDE5 and a longer half-life, which makes it a more suitable choice for the treatment of chronic PAH with once-a-day dosing.
Type	Small Molecule
Weight	Average: 389.404 Monoisotopic: 389.137556111
Structure
Chemical Formula	C₂₂H₁₉N₃O₄
Indication	Tadalafil is indicated for the treatment of erectile dysfunction (ED) and can be used alone or in combination with finasteride for the treatment of benign prostatic hypertrophy (BPH). It is also suitable for the sole treatment of pulmonary arterial hypertension (PAH). And combined with macitentan or other endothelin-1 antagonists.

Mechanism of action

Unlocking the Benefits of Raw Tadalafil Powder: A Versatile PDE5 Inhibitor

Raw tadalafil powder, a potent selective phosphodiesterase 5 (PDE5) inhibitor, offers a range of therapeutic effects with its ability to promote smooth muscle relaxation. It is widely used in the treatment of erectile dysfunction (ED), addressing various underlying causes such as cardiogenic, neurological, vascular, iatrogenic, or endocrine factors. These factors disrupt neuronal signals or directly impact smooth muscle cells, leading to impaired penile smooth muscle function.

During sexual arousal, the release of nitric oxide (NO) by non-adrenergic non-cholinergic (NANC) neurons triggers a cascade of events. NO stimulates guanylate cyclase, converting guanosine triphosphate into cyclic guanosine phosphate (cGMP). Activating the cGMP-dependent kinase (PKG) pathway, cGMP inhibits platelet activation, smooth muscle cell proliferation, and induces apoptosis. PDE5, responsible for breaking down cGMP, attenuates this signaling cascade. Tadalafil, as a PDE5 inhibitor, enhances signaling through the PKG pathway, promoting penile smooth muscle relaxation during sexual arousal by reducing the influx of calcium ions into smooth muscle cells. This relaxation facilitates the filling of the corpus cavernosa with blood, resulting in an erection.

Beyond ED, tadalafil also exhibits therapeutic benefits in pulmonary arterial hypertension (PAH). In PAH, endothelial dysfunction leads to elevated pulmonary blood pressure through multiple mechanisms. Decreased production of vasodilators like NO and prostacyclin, along with increased production of vasoconstrictors such as endothelin-1 and thromboxane, contribute to vasoconstriction and vascular remodeling. Tadalafil supports smooth muscle relaxation by enhancing NO-cGMP signaling, offering therapeutic effects similar to its role in ED.

Furthermore, tadalafil finds application in the treatment of benign prostatic hyperplasia (BPH). BPH, characterized by excessive proliferation of prostate epithelium and smooth muscle, causes urinary dysfunction. Tadalafil's benefits in BPH may not be solely attributed to the relaxation of prostate smooth muscle. Instead, it appears to enhance oxygenation, reduce inflammation, inhibit tissue remodeling, and impede cell proliferation through the cGMP cascade.

Compared to other PDE5 inhibitors, tadalafil exhibits reduced affinity for PDE6, a factor that contributes to visual side effects, as PDE6 is involved in color perception and present in the eyes.

Please note that before using tadalafil or any medication, thorough research and consultation with a healthcare professional are essential to ensure suitability and safety.

Product Function

Experience Enhanced Sexual Performance with Tadalafil Powder

1. Ignite Your Libido in Just 15 to 30 Minutes
With the powerful properties of tadalafil powder, you can expect a rapid onset of action. Activate your libido within a short span of 15 to 30 minutes, paving the way for an exciting and satisfying sexual experience.

2. Extend the Duration of Sexual Intercourse
Say goodbye to premature endings. Tadalafil powder can help you prolong the time of sexual intercourse, allowing you and your partner to indulge in pleasurable moments for an extended period. Enjoy heightened intimacy and make the most of your intimate encounters.

3. Boost Sexual Stamina and Achieve Stronger Erections
Unlock your full potential in the bedroom with the natural benefits of tadalafil powder. Enhance your sexual stamina and experience harder, stronger erections that leave both you and your partner amazed. Rediscover the joy of a fulfilling sex life with renewed confidence and vitality.

4. Effective Treatment for Erectile Dysfunction (ED)
Tadalafil powder is a trusted solution for effectively treating Erectile Dysfunction (ED). Reclaim your sexual prowess and overcome the challenges of ED with this reliable and proven medication. Experience the joy of restored confidence and intimate satisfaction.

5. Safety First: No Harmful Side Effects
Rest assured that tadalafil powder is a safe option for enhancing your sexual performance. With no harmful side effects reported, you can enjoy the benefits of this remarkable powder without compromising your well-being. Prioritize your health while achieving the desired results.

Please note that while tadalafil powder can offer significant benefits, it is important to consult with a healthcare professional before starting any new medication to ensure it is suitable for you and your specific needs.

Product Specification

Items	Specifications	Results
Appearance	White powder	White powder
Dissolve	Methanol ≤0.3% Ethanol ≤0.5% Isopropyl alcohol ≤0.5%	Positive
Identification (high performance liquid chromatography)	Positive	Positive
Loss on drying	＜0.5%	0.12%
Isomer	＜1.0%	0.03%
Total miscellaneous	＜1.0%	0.2%
Assay	＞99.0%	99.73%
Conclusion	Qualified

High Performance Liquid Chromatography

Analysis Information
Product Name		Tadalafil
Operator		David
Injection Date		3/2/2019 4:41:30 AM
Batch No:		2
HPLC Condition
Column:		ZORBAX Eclipse Pluse C18 3.5µm 4.6mmx100mm
Solvent A:		H2O+1‰ TFA
Solvent B:		ACN+1‰ TFA
Gradient:		Time		A		B
		0.0min		95%		5%
		2.0min		95%		5%
		7.0min		5%		95%
		10.0min		0%		100%
		12.0min		0%		100%
		12.1min		95%		5%
		15.0min		Stop		Stop
Flow rate:		1ml/min
Wavelength:		280nm
Volume:		5μ
Result

Rank	RetTime(min) A		*Area(mAUs)**		Area %
1	6.196		6.15344		0.0854
2	6.917		7200.66992		99.9146

Dosage

Optimal Dosage and Usage Guidelines for Tadalafil Powder

1. Recommended Dosage: 10mg for Enhanced Results
For maximum effectiveness, the recommended dosage of tadalafil powder is 10mg. Take this dose before engaging in sexual activity, regardless of food consumption. Start with this dosage and assess its impact on your performance.

2. Adjusting the Dosage: Up to 20mg for Enhanced Effect
If you find that the 10mg dose does not produce the desired effect, you may increase the dosage to 20mg. However, it is important to note that this higher dosage should be taken at least 30 minutes before engaging in sexual activity. This adjustment can help you achieve optimal results.

3. Frequency of Usage: Once a Day for Consistency
To ensure safety and effectiveness, it is recommended to limit the frequency of tadalafil powder usage to once a day. By adhering to this guideline, you can maintain a consistent and appropriate dosage regimen, promoting a healthy and balanced approach to your sexual experiences.

Please remember that individual responses to medications may vary. It is always advisable to consult with a healthcare professional before initiating any changes in dosage or frequency to ensure it aligns with your specific health needs and circumstances.

Interdiction

Important Safety Information for Tadalafil Usage

1. Avoid Nitrates: Contraindication with Tadalafil
Clinical studies have revealed that the combination of tadalafil and nitrates can enhance the antihypertensive effect by acting on the nitric oxide/cGMP pathway. Due to this interaction, it is important to note that tadalafil is contraindicated in individuals taking any form of nitrates.

2. Considerations for Patients with Heart Disease
Sexual activity can pose potential risks to individuals with pre-existing heart conditions. Therefore, medications like tadalafil, used for erectile dysfunction, should not be used in patients with heart disease who have been advised against engaging in sexual intercourse. Physicians should carefully evaluate the cardiac risks associated with sexual activity for patients with pre-existing heart conditions. It is crucial to note that the following cardiovascular conditions were not included in clinical trials, and as such, tadalafil is strictly contraindicated in these groups:

● Patients who have experienced a myocardial infarction within the last 90 days
● Patients with unstable angina or angina occurring during sexual intercourse
● Patients diagnosed with New York Heart Association grade 2 or higher heart failure within the past 6 months
● Patients with refractory arrhythmias, hypotension (<90/50mmHg), or refractory hypertension
● Patients who have had a stroke within the last 6 months

3. Hypersensitivity Reactions: Precautionary Measures
It is important to note that individuals with known hypersensitivity to tadalafil and its prescription ingredients should not take this product. If you have a history of hypersensitivity reactions, it is advised to avoid tadalafil and consult with a healthcare professional for alternative options.

Precautions

1. Prior Medical Assessment: Diagnosis and Evaluation
Before considering drug therapy for male erectile dysfunction, it is crucial to conduct a comprehensive medical history and physical examination. This helps in diagnosing erectile dysfunction and identifying any underlying causes that may be contributing to the condition.

2. Cardiovascular Health and Tadalafil
Physicians should carefully assess the cardiovascular health of men with erectile dysfunction, including the use of tadalafil. The vasodilatory properties of tadalafil can cause a mild, temporary decrease in blood pressure, which may enhance the hypotensive effect of nitrates.

3. Cardiovascular and Hypotensive Risks
Serious cardiovascular events, such as myocardial infarction, unstable angina, ventricular arrhythmia, shock, and transient ischemic attack, have been observed in clinical trials involving tadalafil. Hypertension and hypotension (including orthostatic hypotension) have also been occasionally reported. Many of these patients had pre-existing cardiovascular risk factors, although the relationship between these events and the risk factors is not yet fully understood.

4. Severe Hepatic Impairment and Safety
Limited information is available regarding the safety of tadalafil in patients with severe hepatic impairment (Child-Pugh class C). If prescribing tadalafil to such patients, a careful assessment of the benefits and risks should be conducted by the prescribing physician.

5. Priapism and Immediate Medical Attention
While no priapism has been reported in tadalafil clinical trials, patients should be advised to seek immediate medical attention if they experience erections lasting 4 hours or more. Delayed treatment of priapism can lead to penile tissue damage and permanent loss of erection.

6. Precautions for Specific Conditions
Tadalafil should be used with caution in patients prone to priapism (e.g., sickle cell anemia, multiple myeloma, or leukemia) or those with abnormal penile anatomy (e.g., angulation, penile deformities, cavernous fibrosis) or Peyronie's disease. The effectiveness of tadalafil in patients with spinal cord injuries, pelvic surgery history, or prostatectomy remains unclear.

7. Contraindications and Special Precautions
Tadalafil should not be used in patients with hereditary galactose intolerance, galactolytic enzyme deficiency, or glucose-galactose malabsorption. Concomitant use of tadalafil with alpha-blockers (e.g., doxazosin) is not recommended due to the potential risk of symptomatic hypotension. Special care should be taken when prescribing tadalafil with potent CYP3A4 inhibitors (e.g., ritonavir, saquinavir, ketoconazole, itraconazole, erythromycin), as these may increase tadalafil exposure.

8. Combination with Other Erectile Dysfunction Treatments
The safety and efficacy of combining tadalafil with other treatments for erectile dysfunction have not been studied. Therefore, such combinations are not recommended.

9. Long-term Continuous Administration
Continuous daily administration of tadalafil has not been established for long-term use and is contraindicated.

10. Driving and Operating Machinery
Tadalafil had no significant impact on the ability to drive or operate machinery based on available data. However, patients should be aware of their individual response to tadalafil before engaging in such activities.

About Us

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Shipping Policy

Learn about our shipping methods for international cosmetic ingredients, plant extract and supplements orders. Our international carriers include FedEx, UPS, and DHL Express. Choose a shipping option that best fits your budget and needs. However, in some cases we reserve the right, without notice, to change the shipping service on your order due to high value. UPS will be switched to FedEx Ground and a signature upon delivery will be required. All orders are shipped from our warehouse in China.

International Shipping

We ship to over 150 countries worldwide and have over 4 years of experience dealing with international shipping documentation. Please note that shipping charges may vary from the amount indicated by the automatic shipping calculator since the weight calculated on the website may differ from the actual package weight due to the packaging material. There is no handling fee for all international orders.

Customs fees, VAT, or value added tax, and sales tax are typically charged by the government of your country and must be paid by the customer once the package arrives. We cannot determine what these fees will be. We recommend that you check with your local customs office or post office for details on how these charges are assessed and applied. For customs clearance, a customs broker is usually needed who may charge you a brokerage fee. Packages may be held up in customs for a few days and will delay delivery.

FedEx International Economy: delivers in five business days to more than 220 countries for packages up to 150 pounds. Includes tracking. Extra services include broker service and customs cleared service. Please provide your FedEx account number in the "Shipping Instructions" section of your order if you want to have it shipped on your account. The prepaid shipping cost will be refunded.
FedEx International Priority: delivers in one to three business days and two business days for major cities in Europe. This shipping option is available for more than 220 countries for packages up to 150 pounds. Includes tracking. Extra services include broker service, third party consignee, and customs cleared service. Please provide your FedEx account number in the "Shipping Instructions" section of your order if you want to have it shipped on your account. The prepaid shipping cost will be refunded.

Worldwide Expedited: offers customs-cleared, day-definite delivery to more than 220 countries and territories in two to five business days.
Worldwide Express: this service offers guaranteed delivery in 1-3 business days depending on the destination. Service is available in 185 countries and territories.
Worldwide Saver: offers guaranteed afternoon delivery in 1-3 days for your international shipments. Next business day delivery to Canada, two business days to Europe and Latin America, and two or three business days to Asia. Service is available in 215 countries.

DHL Express Worldwide: DHL offers exclusively express shipping services around the globe. Slower shipping services that take longer than four to five days are not available with DHL. The Express Service is a time-sensitive service with proactive delivery notification available on request. Delivers by the end of the next possible business day. Intercontinental shipments usually take three days.

01. How to contact with us？

Online service:by Trademanager, Skype,Email
You can choose your Interested products and send inquiry to us.
Call us without any hesitation.

02. How to confirm the products quality before placing orders?

We will offer you our products specification standard to you,and we test every batch of our product by HPLC.UV,GC AND TLC AND etc. We also cooperate with independent third party lab such as SGS,PONY etc.
FREE SAMPLES of some products can be sent on request,only need to pay the shipping cost or arrange a courier to us and take the samples. Send us your products specifications and requests, we will produce for you.

03. How to make order & payment?

We can accept payment by TT,WESTERN UNION,Escrow,Paypal,L/C

04. How to pack and storage?

Packing:1kg/Aluminium Floil bag with Carton outside. 25KG/Fiber drum with double PE BAGS INSIDE.
Storage:Store in cool & Dryplace,keep away from light and heat.

05. How to ship and delivery?

Transit could be DHL,UPS,TNT,FEDEX,EMS.For mass orders,it will be ship by air or sea.

06. Our reture service policy

We offer an full money back guarantee,if you are not 100% satisfied with our products,return all goods back to us within 60 days and we will fully refund your money.

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Tadalafil Powder