Product Description

Alpha-Lipoic Acid (α-LA) is a natural antioxidant with very strong antioxidant capacity, which is distributed in the liver tissue of animals and plants such as spinach and tomatoes. After α-LA is absorbed by the human body, it can be rapidly converted into dihydrolipoic acid (DHLA) in the cells and excreted outside the cells.

The combined action of α-LA and dihydrolipoic acid can remove almost all oxidative free radicals in the body, such as OH, H2O2, HClO, 1O2, OONO, NO, ROO , O2-, etc. DHLA has a low redox potential (-0.24V), it can reduce the oxidized glutathione GSSH to GSH, and can also regenerate other endogenous antioxidants such as VE, ascorbic acid and other endogenous antioxidants through redox coupling. Coenzyme Q10, etc.

Alpha-LA is a class of conditionally essential nutrients
 

Product Function

Scavenge free radicals and reactive oxygen species

α-LA scavenges hydroxyl radicals ( OH), (H2O2), singlet oxygen (1O2), nitric oxide radicals (NO ), peroxynitroso ( OONO) and hypochlorous acid (HClO). Although α-LA cannot scavenge peroxide radicals (ROO ) and superoxide radicals (O-2 ), the reduced DHLA of α-LA can scavenge other radicals other than singlet oxygen. Therefore, α- LA and DHLA can scavenge all the above-mentioned free radicals in the process of mutual conversion and metabolic regeneration in vivo.

Interaction with other antioxidants

DHLA is a strong reducing agent that can reduce and regenerate many oxidative antioxidants such as ascorbic acid, vitamin E, glutathione (GSH), coenzyme Q, thioredoxin, etc. The redox of α-LA and DHLA activates the metabolic cycle of other antioxidants in the organism, forming a unique biological antioxidant regeneration cycle network, maintaining the normal level of antioxidants in the body, and jointly exerting biological antioxidant effects.

α-LA also significantly increased intracellular GSH levels. GSH is a water-soluble endogenous antioxidant involved in many important physiological processes. GSH deficiency leads to the production of reactive oxygen species and mitochondrial dysfunction, ultimately leading to neuronal apoptosis. An important biochemical feature of Parkinson's disease (PD) is a significant decrease in GSH levels, so α-LA has a positive effect on the prevention and treatment of PD. The synthesis of GSH in vivo is affected by the availability of cysteine. α-LA can be rapidly absorbed by cells and reduced to DHLA, which is dispersed into various tissues. DHLA reduces cystine to cysteine. Cysteine ​​is absorbed by cells ten times faster than cystine, thereby accelerating GSH biosynthesis. DHLA can increase the concentration of GSH by 30% to 70%.

In the field of medicine, α-LA is widely used in the prevention and adjuvant treatment of diabetes and its related complications.
 

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	183476-82-6	VC-IP/Ascorbyl Tetraisopalmitate		1077-28-7			A-Lipoic Acid
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	497-76-7	Beta Arbutin		497-30-3			Ergothioneine
	53936-56-4	Deoxyarbutin		175357-18-3			Undecylenoyl Phenylalanine/Sepiwhite MSH
	501-30-4	Kojic Acid		331-39-5			Caffeic acid
	79725-98-7	Kojic Acid Dipalmitate		86404-04-8			3-o-ethyl ascorbic acid
	123-31-9	Hydroquinone		103-16-2			Monobenzone
	1105025-85-1	Dimethymethoxyl Chromanyl Palmitate		114040-31-2			Magnesium Ascorbyl Phosphate
	1197-18-8	Tranexamic Acid		66170-10-3			Sodium Ascorbyl Phosphate
	922165-31-9	Neosolue-aqulio		123-99-9			Azelaic Acid
	96702-03-3	Ectoin		84696-21-9			Hydrocotyle Asiatica Extract
	83923-51-7	Dimethylmethoxy Chromanol		90-64-2			Mandelic acid
	79-14-1	Glycolic Acid		73-31-4			Melatonin
	7402-28-0	1,4-Dipropionyloxybenzene		152312-71-5			Potassium 4-Methoxysalicylate/4-MSK
	1077-28-7	A-Lipoic Acid		129499-78-1			Ascorbyl Glucoside/AA2G
	305-84-0	Carnosine		69-72-7			Salicylic Acid/BHA
	497-30-3	Ergothioneine		-			Alpha Hydroxy Acid/AHA
	175357-18-3	Undecylenoyl Phenylalanine/Sepiwhite MSH		83-86-3			Phytic acid
	331-39-5	Caffeic acid		-			Snow White
	98-92-0	Niacinamide		-			Giga White
	90082-87-4	Plum, ext		-			Glabridin
	36062-04-1	Tetrahydrocurcumin		36062-04-1			Tetrahydrocurcuminoids
	85-27-8	Symwhite 377/Phenylethyl Resorcinol		68797-35-3			Dipotassium Glycyrrhizinate
	922165-31-9	Neosolue-aqulio		19771-63-2			Procysteine

 

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