Alpha-Lipoic Acid (α-LA) is a natural antioxidant with very strong antioxidant capacity, which is distributed in the liver tissue of animals and plants such as spinach and tomatoes. After α-LA is absorbed by the human body, it can be rapidly converted into dihydrolipoic acid (DHLA) in the cells and excreted outside the cells.
The combined action of α-LA and dihydrolipoic acid can remove almost all oxidative free radicals in the body, such as OH, H2O2, HClO, 1O2, OONO, NO, ROO , O2-, etc. DHLA has a low redox potential (-0.24V), it can reduce the oxidized glutathione GSSH to GSH, and can also regenerate other endogenous antioxidants such as VE, ascorbic acid and other endogenous antioxidants through redox coupling. Coenzyme Q10, etc.
Alpha-LA is a class of conditionally essential nutrients
|Product Name||Alpha-Lipoic Acid|
|Appearance||Yellow Crystalline Powder|
|Package||1kg/aluminum foil bag; 25kg/drum|
|Shelf life||2 Years|
Scavenge free radicals and reactive oxygen species
α-LA scavenges hydroxyl radicals ( OH), (H2O2), singlet oxygen (1O2), nitric oxide radicals (NO ), peroxynitroso ( OONO) and hypochlorous acid (HClO). Although α-LA cannot scavenge peroxide radicals (ROO ) and superoxide radicals (O-2 ), the reduced DHLA of α-LA can scavenge other radicals other than singlet oxygen. Therefore, α- LA and DHLA can scavenge all the above-mentioned free radicals in the process of mutual conversion and metabolic regeneration in vivo.
Interaction with other antioxidants
DHLA is a strong reducing agent that can reduce and regenerate many oxidative antioxidants such as ascorbic acid, vitamin E, glutathione (GSH), coenzyme Q, thioredoxin, etc. The redox of α-LA and DHLA activates the metabolic cycle of other antioxidants in the organism, forming a unique biological antioxidant regeneration cycle network, maintaining the normal level of antioxidants in the body, and jointly exerting biological antioxidant effects.
α-LA also significantly increased intracellular GSH levels. GSH is a water-soluble endogenous antioxidant involved in many important physiological processes. GSH deficiency leads to the production of reactive oxygen species and mitochondrial dysfunction, ultimately leading to neuronal apoptosis. An important biochemical feature of Parkinson's disease (PD) is a significant decrease in GSH levels, so α-LA has a positive effect on the prevention and treatment of PD. The synthesis of GSH in vivo is affected by the availability of cysteine. α-LA can be rapidly absorbed by cells and reduced to DHLA, which is dispersed into various tissues. DHLA reduces cystine to cysteine. Cysteine is absorbed by cells ten times faster than cystine, thereby accelerating GSH biosynthesis. DHLA can increase the concentration of GSH by 30% to 70%.
In the field of medicine, α-LA is widely used in the prevention and adjuvant treatment of diabetes and its related complications.
Browse our wide selection active whitening ingredients
Skin whitening products are commercially available for cosmetic purposes in order to obtain a lighter skin appearance. They are also utilized for clinical treatment of pigmentary disorders such as melasma or postinflammatory hyperpigmentation.
Whitening agents act at various levels of melanin production in the skin. Many of them are known as competitive inhibitors of tyrosinase, the key enzyme in melanogenesis.
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