Glutathione (glutathione GSH) is a tripeptide containing sulfhydryl groups combined with glutamic acid, cysteine and glycine, and has antioxidant and integrated detoxification effects. The sulfhydryl group on cysteine is the active group of glutathione (so glutathione is often abbreviated as G-SH), which is easy to interact with certain drugs (such as paracetamol), toxins (such as free radicals, iodoacetic acid, mustard gas, lead, mercury, arsenic and other heavy metals), and has integrated detoxification effect. Therefore, glutathione (especially glutathione in liver cells) can participate in biotransformation, so as to convert harmful toxins in the body into harmless substances and excrete them out of the body. Glutathione also helps maintain normal immune system function.
Glutathione has two forms, reduced (G-SH) and oxidized (G-S-S-G), and reduced glutathione accounts for the vast majority under physiological conditions. glutathione reductase
Interchange between the two types. The coenzyme of this enzyme is NADPH provided by the alternative metabolism of sugar phosphate.
Uses: Antidote, mainly used for poisoning of heavy metals, acrylonitrile, fluoride, carbon monoxide and organic solvents.
In medicine, reduced glutathione is a small molecule peptide, which exists in large quantities in living organisms, especially in liver cells. It can protect liver cell membranes and promote liver enzyme activity. And combined with many toxic chemicals to play a role in detoxification. It has a good curative effect on liver injury, liver cirrhosis and other diseases caused by drug poisoning, alcoholism and other reasons. other role has:
1. Adding it to the flour products can play a reducing role. It not only shortens the time of making bread to one-half or one-third of the original, but also greatly improves labor conditions, and plays a role in strengthening food nutrition and other functions.
2. Add it to yogurt and baby food, which is equivalent to vitamin C and can play the role of stabilizer.
3. Mix it into the fish cake to prevent the color from deepening.
4. When added to meat products and cheeses, it has the effect of enhancing the flavor.
Glutathione is a tripeptide compound formed by the condensation of glutamic acid, cysteine and glycine through peptide bonds. It is the most important low-molecular-weight thiol in mammalian cells against oxidative stress. It was discovered in 1921 and the chemical structure was determined in 1930. Dr. Al Mindel, a famous American nutrition and health care expert, called glutathione an anti-aging amino acid with three times the potency, also known as nature's anti-oxidant master, with the appearance of Colorless transparent slender granular crystal, soluble in water, dilute alcohol, liquid ammonia, dimethylformamide, insoluble in ethanol, ether, acetone. When it is solid, its properties are stable, and its aqueous solution is easily oxidized to oxidized glutathione in the air, which is widely found in baker's yeast, wheat germ, animal liver, chicken blood, pig blood, tomatoes, pineapples, and cucumbers, among which wheat The highest in germ and animal liver, the content is as high as 100 ~ 1000mg/100g. It has the functions of anti-oxidation, scavenging free radicals, detoxification, enhancing immunity, anti-aging, anti-cancer, and anti-radiation hazard. Also helps white blood cells kill bacteria, prevents oxidation of vitamins C and E, and prevents stroke and cataract formation. In addition, glutathione also binds carcinogens and excretes them through urine.
The liver is the most important detoxification organ in the human body, and the rich glutathione (GSH) contained in it plays a protective role in the synthesis, detoxification, and estrogen inactivation of the liver. It is the body's primary antioxidant to counteract the damage of free radicals, which are contributing factors to aging and disease. When the liver is damaged, such as suffering from various liver diseases, the human body will consume a large amount of GSH to help the injured liver to repair and detoxify itself, resulting in a significant decrease in glutathione in the body. At this time, we need to take some glutathione drugs to help the injured liver repair itself. Therefore, glutathione drugs are suitable for viral hepatitis (such as hepatitis A, hepatitis B, etc.), alcoholic liver disease, drug-induced liver disease, fatty liver and other liver diseases, and are good liver protection medicines for patients with liver diseases.